Generic treatment for 8 weeks led to a reduction of mean sitting diastolic blood pressure of 10.3 mmHg (compared to 10.7 mmHg in the group treated with branded irbesartan). The study showed similar reductions in blood pressure at both 4 and 8 weeks for generic and branded irbesartan. The phase IV study included 177 patients who were followed for 8 weeks. Ī recently published study compared the efficacy and safety of generic vs branded irbesartan in patients with mild-to-moderate hypertension. A generic version of irbesartan was approved in the US in 2012. Irbesartan (sold by Sanofi under the trade name Avapro) is a commonly prescribed ARB, with more than 3.6 million prescriptions filed in the US in 2016 alone. As such their use has increased in recent years (use of ARBs doubled between 20 in the US). Angiotensin II receptor blockers (ARBs) offer similar long-term reductions in blood pressure but with fewer withdrawals due to adverse events (AEs). However, side effects of ACE inhibitors include a dry cough and swelling beneath the skin (angioedema). Treatments for hypertension include angiotensin-converting-enzyme (ACE) inhibitors which cause blood vessels to relax and decrease blood volume. Although common, hypertension can have serious consequences, including heart attack and stroke, if not diagnosed and treated early. Hypertension, or high blood pressure, is the most common condition seen in primary care, a burden which is increasing as the population ages.
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